Prevention of Atrial Fibrillation Following Noncardiac Thoracic Surgery

• Status: Completed
• Trial end date: 2008-02-01
• Target enrollment: 0
• Participant gender: All

Summary

The investigators hypothesize that the medication amiodarone decreases the incidence of atrial fibrillation (AF) following non-cardiac open-chest surgery. Their specific aims are to:

• Determine the effectiveness of amiodarone for the prevention of AF following non-cardiac open-chest surgery;

• Determine the influence of the prevention of AF following non-cardiac thoracic surgery on post-surgical duration of stay in the Intensive Care Unit (ICU); post-surgical duration of stay in a hospital unit that employs cardiac monitoring; and duration of post-surgical hospital stay; and

• Determine the safety of amiodarone for the prevention of AF following non-cardiac open-chest surgery.

• Phase: Phase 4
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Indiana University
• Collaborator: Purdue University
• Treatments: Amiodarone

Criteria

Inclusion Criteria:

• Males or females over the age of 40

• Scheduled to undergo pneumonectomy or lobectomy

Exclusion Criteria:

• History (hx) of atrial fibrillation

• Prior severe side effects from amiodarone

• Elevated liver enzymes >3 times the upper limit of normal (UNL)

• QTc interval > 450 ms

• Receiving class Ia or class III antiarrhythmics