Prevention of Contrast-Induced Nephropathy in Diabetic Patients With Undergoing Coronary Angiography

• Status: Unknown status
• Trial end date: 2010-01-01
• Target enrollment: 0
• Participant gender: All

Summary

The aim of this study is to determine whether sodium bicarbonate is superior to sodium chloride in preventing contrast induced nephropathy in diabetic patients undergoing coronary angiography or intervention.

• Phase: Phase 4
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: CardioVascular Research Foundation, Korea

Criteria

Inclusion Criteria:

• age>18 years, no upper limits

• diabetes treated with insulin or oral hypoglycemic agents

• serum creatinine >=1.1 and

• resting estimated glomerular filtration rate <60ml/min/1.73 square meter

Exclusion Criteria:

• serum creatinine >=8mg/dL

• resting estimated GFR <15ml/min/1.73 square meter

• end stage renal disease on hemodialysis

• multiple myeloma

• uncontrolled hypertension (systolic BP >160mmHg or diastolic BP>100mmHg)

• acute myocardial infarction

• emergent coronary angioplasty or angiography

• recent use of contrast within 2 days

• allergic reaction to contrast

• pregnancy

• allergic to following medication : theophylline, dopamine, mannitol, fenoldopam, N-acetylcysteine