Prevention of Contrast-Induced Nephropathy

• Status: Completed
• Trial end date: 1969-12-31
• Target enrollment: 0
• Participant gender: All

Summary

Patients with pre-existing kidney disease are at high risk of acute renal failure when exposed to radio-contrast dyes, for example during a cardiac angiogram.

The investigators hypothesize that an infusion of saline + furosemide + mannitol will reduce rates of contrast-induced nephropathy when compared with saline infusion controls.

• Phase: N/A
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: University of Alberta
• Collaborator: Alberta Heritage Foundation for Medical Research
• Treatments: Furosemide; Mannitol

Criteria

Inclusion Criteria:

• age > 21 years

• serum creatinine > 150 umol/L

• able and willing to provide informed consent

Exclusion Criteria:

• known hypersensitivity to contrast, furosemide, or mannitol

• unable to tolerate a fluid load (e.g., acute pulmonary edema)

• ESRD, on dialysis

• previous enrollment in this study or previous contrast administration with the last 2 weeks

• refusal by treating physician