Prevention of Dry Socket by Means of Single Preoperative Antibiotics Compared to Conventional Therapy

• Status: Completed
• Trial end date: 2019-04-15
• Target enrollment: 0
• Participant gender: All

Summary

Background: One of the commonest post-operative complications after tooth extraction is dry socket; it can be defined as postoperative pain in and around the tooth extraction site, which increases in severity at any time between 3rd to 5th post-operative days along with disintegrated blood clot within the tooth extraction socket with or without halitosis. The exact etiology is unclear therefor prevention remains the main beneficial therapy. Various factors are thought to play an important role in etiology of dry socket including, anaerobes, fibrinolysis, traumatic extractions, frequent spiting and rinsing, oral contraceptive pill and smoking.

Numerous approaches have been tried for prevention of dry socket; include antiseptic mouthwashes, anti-fibrinolytic agents, antibiotics, intra-socket dressings and medicated packing into the extraction wound for example chlorohexidine mouthwashes, warm saline rinses, gelatin sponges, occlusive dressings and oxidized cellulose sponge.

Purpose of the study is to compare the role of single preoperative oral dose of metronidazole with amoxicillin in hindrance of dry socket compared to conventional therapy after removal of mandibular third molar of class 2 impaction.

Objectives: To find out effective treatment for prevention of dry socket among preoperative single oral dose of metronidazole and amoxicillin compared to conventional therapy.

Methods: A double blind randomized control trial in which patients requiring surgical extraction of lower 3rd molar of class 2 impactions were selected for this study. Patients were randomly divided into 3 groups, one of the groups had received single preoperative oral dose of metronidazole one hour before extraction, second group was treated with single oral dose of amoxicillin an hour before tooth extraction and third group was treated with conventional therapy. Patients were asked to visit on 5th postoperative day or before it in case the pain persist or reoccur.

• Phase: Phase 2
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: Dow University of Health Sciences
• Treatments: Amoxicillin; Metronidazole

Criteria

Inclusion Criteria:

• Patients requiring surgical extraction of lower third molars with class 2 impaction.

• Males and females were included.

• Age range of the patients was between 18 to 40 years.

• Exclusion Criteria:

• Non-surgical extractions, extractions of other then lower molars,

• Infected tooth.

• tooth with grade 3 or greater mobility.

• Reluctant to participate.

• Pregnant ladies.

• Nursing mothers.

• Alcoholic patients.

• Smokers.

• Patients taking oral contraceptives.

• Patient already taking antibiotics.

• Allergic to amoxicillin and metronidazole.

• Patients on anticoagulant therapy i.e. warfarin, nicoumalone, phenytoin, fluocil.

• Those with severe renal and hepatic dysfunction.