Prevention of Intraoperative Nausea and Vomiting During Cesarean Section

• Status: Completed
• Trial end date: 2011-04-01
• Target enrollment: 0
• Participant gender: Female

Summary

The study investigates the incidence of intraoperative nausea and vomiting under spinal anesthesia using a phenylephrine infusion with and without prophylactic antiemetics.

• Phase: N/A
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Duke University
• Collaborator: IWK Health Centre
• Treatments: Metoclopramide; Ondansetron; Oxymetazoline; Phenylephrine

Criteria

Inclusion Criteria:

• English speaking ASA I-II non-laboring women with single gestations ≥36 weeks

• Scheduled or unscheduled cesarean delivery under spinal anesthesia

• Height: 5 feet-5 feet 11 in.

Exclusion Criteria:

• Laboring women needing an emergency cesarean delivery

• Subjects less than 18 years of age

• Receipt of a drug with antiemetic properties in the 24 hours prior to cesarean section

• Allergy to ondansetron, or metoclopramide

• Severe hypertensive disease of pregnancy defined as systolic blood pressure (SBP)>160mmHg, diastolic blood pressure (DBP)>110mmHg requiring antihypertensive treatment or associated with significant proteinuria.

• Severe Cardiac disease in pregnancy with marked functional limitations

• Diabetes type I

• Patients on Monoamine Oxidase Inhibitors or Tricyclic Antidepressants

• Morbid obesity (body mass index (BMI)>45)

• Inclusion in another anesthetic study involving drug administration