Prevention of Low Blood Pressure in Persons With Tetraplegia

• Status: Completed
• Trial end date: 2010-06-01
• Target enrollment: 0
• Participant gender: All

Summary

The aim of this investigation is to determine the blood pressure response to NOS inhibition, with L-NAME, in persons with tetraplegia compared to non-SCI control subjects and to establish if blood pressure can be increased while upright in those with tetraplegia. If blood pressure is increased with NOS inhibition in persons with tetraplegia, this would improve our treatment of the condition of low blood pressure during seated postures in individuals with tetraplegia.

• Phase: Phase 2/Phase 3
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: US Department of Veterans Affairs; VA Office of Research and Development
• Treatments: Nitric Oxide

Criteria

Inclusion Criteria:

• 18 to 65 year olds.

• Non-ambulatory Chronic tetraplegia (1 year after acute SCI).

Exclusion Criteria:

• central nervous system disease (other than SCI) e.g., multiple sclerosis, amyotrophic lateral sclerosis, syringomyelia, tabes dorsalis;

• peripheral neuropathies;

• surgical sympathectomy;

• coronary heart and/or artery disease;

• anemia;

• hypertension;

• renal function abnormalities;

• diabetes mellitus;

• pituitary insufficiency;

• adrenal insufficiency;

• hypothyroidism; and

• medications known to affect the cardiovascular system.