Prevention of Ocular Graft-Versus-Host Disease With Topical Cyclosporine in Recipients of Allogeneic HSCT

• Status: Completed
• Trial end date: 2016-02-01
• Target enrollment: 0
• Participant gender: All

Summary

Ocular Graft Versus Host Disease (OGVHD) is a serious potential complication of allogeneic bone marrow transplants. The usual treatment is topical cyclosporine but when the treatment is initiated the damage to the lacrimal glands has already taken place.

The present study aims to prevent OGVHD in reduced-intensity allogeneic hematopoietic transplants by using topical cyclosporine immediately after the engraftment has been achieved

• Phase: Phase 2
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Hospital Universitario Dr. Jose E. Gonzalez
• Treatments: Cyclosporine; Cyclosporins

Criteria

Inclusion Criteria:

• Patients who have written consent wishing to participate in the study

• Patients who have received an allogeneic stem cell hematopoietic transplants performed with a reduced intensity conditioning regimen

• >18 year old

Exclusion Criteria:

• <18 year old

• Patients not wishing to participate in the study or have

• Patients who have received autologous stem cell hematopoietic transplants

• Patients with history of rheumatologic diseases

• Patients with a previous diagnosis of dry eye síndrome

• Patients with previous eye surgery that disrupts corenal integrity