Prevention of Postop Atrial Fibrillation Through Intraoperative Inducibility of Atrial Fibrillation and Amiodarone Treatment

• Status: Recruiting
• Trial end date: 2050-12-31
• Target enrollment: 0
• Participant gender: All

Summary

Patients undergoing first time cardiac surgery will undergo rapid atrial pacing prior to initiation of cardiopulmonary bypass to screen for AF inducibility. Patients with inducible AF will be randomized to prophylactic amiodarone treatment versus no treatment. Patients who are not inducible to AF will be treated with standard post-operative care. Patients will be monitored post-operatively to explore the value of intraoperative inducibility of AF to predict POAF and to evaluate whether the combination of intraoperative inducibility and precision amiodarone therapy is effective at reducing the incidence of POAF

• Phase: Phase 4
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: Stanford University
• Treatments: Amiodarone

Criteria

Inclusion Criteria:

• Patients scheduled for first-time non-emergent open-heart surgery for coronary artery bypass graft (CABG) revascularization, valvular repair or replacement, combined CABG with valve repair or replacement, or valve sparing aortic root repair

• Normal sinus rhythm

• No documented history of atrial fibrillation

Exclusion Criteria:

• Prior surgical procedures involving heart surgery and cardiopulmonary bypass

• Any prior documented history of atrial fibrillation, atrial flutter or atrial tachycardia lasting longer than 30 seconds

• Prior history of Amiodarone treatment for the management of supraventricular tachy-arrhythmias

• Patients requiring surgical treatment of atrial arrhythmias such as pulmonary vein isolation or Maze procedure.