Prevention of Postoperative Delirium With Donepezil
Status:
Completed
Trial end date:
2009-03-01
Target enrollment:
Participant gender:
Summary
Patients undergoing hip or knee joint replacement at the age of 70 years or above who are
cognitively unimpaired will receive donepezil or matching placebo before (over 5-7 days),
during and after (over 7 days) surgery. The incidence of delirium will be monitored at 3
days, 7 days, and 49 days following surgery. We hypothesize that the incidence of delirium
can be lowered from 20 per cent to 10 per cent by the intervention.