Prevention of Postpartum Haemorrhage With Sublingual Misoprostol or Oxytocin
Status:
Completed
Trial end date:
2008-01-01
Target enrollment:
Participant gender:
Summary
Sublingual misoprostol produces rapid peak concentration and is more effective than oral
misoprostol for prevention of excessive postpartum bleeding. The study hypothesis was to test
whether women receiving sublingual misoprostol for prevention of postpartum hemorrhage have
30 ml less average blood loss than women receiving oxytocin, the standard of care for
prevention of postpartum hemorrhage. We conducted a Double blind randomized controlled trial
of .652 consenting, eligible pregnant women admitted to the labor room of the teaching
hospital at J N Medical College, Belgaum, India. Women participating in the study were
assigned by computer generated randomization to receive the study medications and placebos
within one minute after clamping and cutting the umbilical cord. We also looked at the drugs
effects on postpartum blood loss at or above ≥500 ml (considered hemorrhage), and the percent
of women experiencing more than a 10% decline in haemoglobin, and reported drug side effects.