Prevention of Prostate Cancer With Dutasteride in Case of High Grade PIN Neoplasia
Status:
Completed
Trial end date:
2010-12-01
Target enrollment:
Participant gender:
Summary
Patients with diagnosis of HPIN were enrolled. Patients were randomized into two groups:
dutasteride treatment group and watchful waiting strategy group. According to the study
protocol the subjects would undergo 10 core biopsies after 6, 12, 24, and 36 months after
randomization.
There are assessed the rate of prostate cancer at repeated transrectal ultrasound guided
biopsies and the effect of 5 alfa reductase inhibitor (dutasteride) on prevention of prostate
cancer development for patients with high grade intraepithelial neoplasia (HPIN).