Prevention of Stroke by Left Atrial Appendage Closure in Atrial Fibrillation Patients After Intracerebral Hemorrhage
Status:
Recruiting
Trial end date:
2030-05-01
Target enrollment:
Participant gender:
Summary
Intracerebral hemorrhage (ICH) in patients with non-valvular atrial fibrillation (NVAF) poses
a particular dilemma for thromboprophylaxis. Left atrial appendage occlusion (LAAO) is a
non-pharmacological approach to prevent cardiac embolism in NVAF. The risk-benefit ratio of
LAAO in patients with NVAF after ICH is unknown. The aim of STROKECLOSE is to assess the
effect of LAAO to reduce the incidence stroke, bleeding and cardiovascular mortality in
patients with NVAF and prior ICH.