Prevention of Surgical Site Infections: Effectiveness of Nasal Povidone-Iodine and Nasal Mupirocin
Status:
Completed
Trial end date:
2012-09-01
Target enrollment:
Participant gender:
Summary
We hypothesize the application of mupirocin or povidone-iodine to the nares is equally
effective in short term Staphylococcus aureus(SA)suppression. Our overall study objective is
to measure the rate of deep and superficial Surgical Site Infections (SSIs) after primary
hip, knee, shoulder and elbow arthroplasty surgery and primary spinal fusion surgery
requiring implantation of prosthetic material, when the patient receives either nasal
mupirocin or nasal povidone-iodine prior to surgery.
Secondary study objectives include:
1. Measure hospital length of stay and re-admission rates in the mupirocin and
povidone-iodine groups.
2. Measure adverse events related to mupirocin and povidone-iodine.
3. Measure rate of SA resistance to mupirocin.