Prevention of Tuberculosis in Prisons

• Status: Terminated
• Trial end date: 2019-08-10
• Target enrollment: 0
• Participant gender: Male

Summary

The purpose of this study is to determine if the isoniazid is effective in the prevention of tuberculosis in a prison population, exposed to the high endemicity of the disease.

• Phase: Phase 4
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: Federal University of Mato Grosso; Federal University of Mato Grosso do Sul
• Collaborator: Oswaldo Cruz Foundation
• Treatments: Anti-Bacterial Agents; Isoniazid

Criteria

Inclusion criteria:

• Age above 18 and under 45 at the time of inclusion;

• Sign the informed consent form.

Exclusion criteria:

• Be indigenous;

• Active TB or previous use of isoniazid;

• Score Alcohol Use Disorders Identification Test ≥15.

• Reactive serology for HIV, hepatitis B and C;

• Reactive result for quantiferon, considering as positive the result of Tube 1 and / or Tube22 above 0.2 IU / mL;

• Liver enzymes (Aspartate aminotransferase and Alanate aminotransferase) three times the upper limit;

• History or treatment for epilepsy;