Prevention of the Progression of Coronary Calcification With Use of Spironolactone in Peritoneal Dialysis Patients
Status:
Completed
Trial end date:
2016-11-10
Target enrollment:
Participant gender:
Summary
Vascular calcification is a frequent complication in dialysis patients and is strongly
associated with mortality. Its pathogenesis is complex and involves a series of markers that
act on the vascular microenvironment. There is evidence that aldosterone is one of the
biomarkers and may have a role in osteoinductive pathways.The aim of this study was to
evaluate the effect of spironolactone, an inhibitor of mineralocorticoid receptor, in the
progression of coronary calcification in patients undergoing peritoneal dialysis.
Phase:
Phase 3
Details
Lead Sponsor:
Professor Fernando Figueira Integral Medicine Institute