Preventive Antibiotic Serum Levels During Caesarean Section

• Status: Unknown status
• Trial end date: 2019-08-01
• Target enrollment: 0
• Participant gender: Female

Summary

Background

Preventive antibiotic treatment before performing invasive procedures is a basic element in preventing infections. The essence of preventive antibiotic treatment is strengthening the defense mechanisms of the immune system by preserving a certain drug levels in the blood. The timing of giving the antibiotics is very important. Several research groups have tried to check the levels of Cefazolin (the most common antibiotics in the field of obstetrics) in serum and adipose tissue in women during cesarean. These groups presented conflicting research results.

OBJECTIVE

This study will discuss the preventive antibiotic treatment levels accepted prior cesareans, to determine:

1. What are the factors affecting the level of drug in the blood?

2. Is there a fixed time which beyond it, blood drug levels are below the MIC(Minimal Inhibitory Concentration)?

3. Is the provision of usual preventive care also addresses the situations of metabolic disorder?

• Phase: Phase 3
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: Tel-Aviv Sourasky Medical Center
• Treatments: Anti-Bacterial Agents; Antibiotics, Antitubercular; Cefazolin

Criteria

Inclusion Criteria:

1. Gestational age of 37 weeks and above.

2. Women who arrive to elective cesareans.

3. Age of women: 18-50 years old.

Exclusion Criteria:

1. Suspected clinical / laboratory active infection

2. urgent surgery

3. Sensitivity to penicillin or cephalosporins antibiotics that requires antibiotics change.

4. Women who received the week before surgery antibiotic treatment