Preventive Application of GnRH Antagonist on Early OHSS

• Status: Unknown status
• Trial end date: 2018-03-01
• Target enrollment: 0
• Participant gender: Female

Summary

Ovarian hyperstimulation syndrome is an iatrogenic complication of controlled ovarian stimulation. Ovarian hyperstimulation syndrome prevention is a multistage process and more important than treatment.Preventive administration of GnRH antagonist for high risk OHSS patients from the day of oocyte retrieval is not investigated. Besides, the relevant mechanism is not clear yet. Here we designed a prospective randomized study to investigate whether GnRH anatagonist treatment after oocyte retrieval is more effective in preventing early ovarian hyperstimulation syndrome development than traditional aspirin preventive administration in women at high risk for OHSS.

• Phase: Phase 4
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: First Affiliated Hospital, Sun Yat-Sen University
• Treatments: Ascorbic Acid; Aspirin; Prolactin Release-Inhibiting Factors; Vitamins

Criteria

Inclusion Criteria:

• number of oocyte retrieval more than 25;

• estradiol level higher than 5000pg/mL on the day of human chorionic gonadotropin administration;

• clinical or ultrasonography proven ovarian hyperstimulation syndrome on the day of oocyte retrieval.

Exclusion Criteria:

• contraindications to GnRH antagonist;

• coasting or other preventive measures for managing ovarian hyperstimulation syndrome had been applied;

• GnRH agonist for trigger.