Preventive Effects of Low Dose Droperidol on the Postoperative Delirium in Non-cardiac Surgery of Elderly Patients

• Status: Not yet recruiting
• Trial end date: 2024-12-31
• Target enrollment: 0
• Participant gender: All

Summary

The aim of this multicenter, prospective, randomized, double-blind and large sample study is to explore the preventive effect of low-dose droperidol on POD in elderly patients after non-cardiac surgery, providing new approach for reducing the incidence of POD and improving the prognosis and quality of life.

• Phase: N/A
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: RenJi Hospital
• Treatments: Droperidol

Criteria

Inclusion Criteria:

• Age≥65 years and <80 years

• American Society of Anesthesiologists (ASA): I-III

• Planning to undergo elective non-cardiac surgery under general anesthesia with endotracheal intubation, including digestive, spinal, urologic and gynecological surgery

• Estimated operation time more than 2 hours

• Not admitted to ICU after surgery

• Proficient in Chinese

• Voluntary signature of informed consent

Exclusion Criteria:

• Morbid obesity with BMI >35;

• History of psychological and neurological diseases, such as depression, schizophrenia, epilepsy, severe central nervous system depression, Parkinson's disease, Alzheimer's disease, myasthenia gravis, basal ganglia disease, etc;

• Corrected QT (QTc) of electrocardiogram> 500ms;

• Preoperative liver insufficiency (Child Pugh grade C);

• Preoperative renal insufficiency (Dialysis required);

• Severe heart failure [Metablic equivalent (METs)<4];

• Allergic to droperidol;

• Inability to communicate due to coma or dementia in preoperative period;

• Delirium before operation;

• Alcohol abuse;

• Participating in other clinical trials;

• Planning to receive second operation within 7 days after first operation.