Preventive and Reversional Effect of Vitamin D on Parenteral Nutrition Associated Liver Disease
Status:
Unknown status
Trial end date:
2016-02-01
Target enrollment:
Participant gender:
Summary
Patients who accept long-term parenteral nutrition tend to suffer from liver injury. The
mechanism for this injury has two possible explanations. The first possible reason is
intrinsic toxic effects of parenteral nutrition. The second is the basic pathological
condition of intestinal failure which includes infection, bacterial translocation, etc.
Cholestasis is the lethal presentation of this kind of liver disease. Farnesoid X receptor
(FXR) is a member of ligand-activated nuclear receptor superfamily. FXR serves as a sensor
for bile acids and promotes enterohepatic clearance of bile acids by controlling the
expression of genes involved in their transport and metabolism. Considering the activation of
vitamin D receptor (VDR) by vitamin D can induce FXR-related genes in the liver.The
hypothesis of this study is that vitamin D plays a key role in the prevention and reversion
of the liver via VDR and/or FXR signaling pathway. Using a mouse cholestasis model based on
short bowel syndrome and parenteral nutrition, the researchers will investigate the dynamic
change of plasma vitamin D level. Afterward, intravenous supplement of vitamin D was added to
this model to demonstrate vitamin D can ameliorate cholestasis. An in vitro system was
developed to investigate the importance of FXR signaling pathway in this effect.