Primary Cardiovascular Risk Prevention With Aspirin in Chronic Kidney Disease Patients

• Status: Unknown status
• Trial end date: 2015-05-01
• Target enrollment: 0
• Participant gender: All

Summary

The objective of the study is to examine whether the use of low-dose aspirin (75-100 mg / day) reduces the risk of cardiovascular disease in patients with chronic kidney disease (stage 3 or 4).

• Phase: Phase 3
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Fundación de Ayuda a la Investigación sobre la Hipertensión, Riesgo Cardiovascular y Enfermedades Renales
• Treatments: Aspirin

Criteria

Inclusion Criteria:

• sign informed consent

• males 45-79 years or females 55-79 years. -Stage 3 or 4 CKD (estimated GFR by MDRD abbreviated, between 15 and 60 ml / min/1.73 m2) -

Exclusion Criteria:

• a previous cardiovascular event: cardiac arrhythmias, cardiac arrest, angina or acute myocardial infarction, stroke, carotid stenosis of more than 50%, peripheral vascular arteriopathy documented

• hospitalization for any cause in the last three months prior to inclusion in the study allergy of acetyl-salicylic acid

• coagulopathy from any cause

• thrombocytopenia <150,000 platelets

• liver disease from any cause

• Infection by hepatitis B virus, hepatitis C or HIV

• immunosuppressive treatment within 12 weeks before inclusion in the study

• Major bleeding events including gastrointestinal bleeding and brain hemorrhage.

• hemoglobinopathies (eg sickle cell disease or thalassemia of any kind)

• active malignancy (except non-melanoma skin cancer). May be included in the study patients with malignant neoplasia who have remained disease-free for at least the previous 5 years.

• uncontrolled inflammatory disease or symptomatic (eg rheumatoid arthritis, lupus, Chrom disease or bowel inflammatory disease)

• hemolysis

• treatment with oral anticoagulation and / or antiplatelet therapy prior.

• poorly controlled hypertension (> 160/90 mm Hg) -pregnancy or breast-

• women of childbearing potential not using effective contraception.