Primary Prevention of Cardiovascular Disease (CVD) in Pre-diabetic & Pre-hypertensive Subjects

• Status: Unknown status
• Trial end date: 2016-12-01
• Target enrollment: 0
• Participant gender: All

Summary

The purpose of this study is to determine whether treating pre-diabetic & pre-hypertensive individuals using multiple drugs intervention (anti-hypertensive drugs (i.e., ACEI) plus anti-glycemic drug (i.e., metformin) plus anti-hyperlipidemic drug (statin)) would lower Cardiovascular Disease (CVD) events.

• Phase: N/A
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: Ramathibodi Hospital
• Collaborators: National Health Security Office, Thailand; The Government Pharmaceutical Organization; Ubon Ratchathani Public Health Office, Thailand
• Treatments: Enalapril; Enalaprilat; Metformin; Simvastatin

Criteria

Inclusion Criteria:

• Pre-diabetes

• Pre-hypertensives

• LDL-Cholesterol >= 100 < 190 mg/dl

• BMI >= 23

• Estimated GFR >= 60 ml/min/1.73 m2 (MDRD equation)

• Willing to participate and provide written inform consent

Exclusion Criteria:

• Current involved in other studied medications

• Regular use of corticosteroids

• Current use of weight loss medication

• History of renal disease

• Active liver disease including jaundice, chronic hepatitis with ALT >= 2.5 the upper normal limit

• Active malignancy

• Major psychiatric disorder

• Diseases and medications that affect glucose tolerance (e.g. pheochromocytoma, Cushing's syndrome, acromegaly, steroid-dependent asthma, protease inhibitors, antipsychotics)

• Nursing women, pregnant women, or those that plan to become pregnant in the study period