Primary Prevention of Hypertension in Obese Adolescents
Status:
Completed
Trial end date:
2011-01-01
Target enrollment:
Participant gender:
Summary
The purpose of this study is to examine the consequences of lowering serum uric acid in
pre-hypertensive, obese adolescents pathways involved with how uric acid mediated
hypertension and renal disease. The specific aims are:
1. Test the hypothesis that lowering uric acid will improve endothelial function.
2. Test the hypothesis that lowering uric acid will reduce plasma renin activity and serum
angiotensin II levels.
3. Test the hypothesis that lowering uric acid will reduce markers of inflammation
Phase:
Phase 2
Details
Lead Sponsor:
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)