Primary Prophylaxis of Hepatic Encephalopathy in Patients With Cirrhosis

• Status: Unknown status
• Trial end date: 2010-09-01
• Target enrollment: 0
• Participant gender: All

Summary

To assess the effects of lactulose for the prevention of first episode of altered sensorium (hepatic encephalopathy, primary prophylaxis) in patients with cirrhosis.

• Phase: Phase 4
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Govind Ballabh Pant Hospital
• Treatments: Lactulose

Criteria

Inclusion Criteria:

• cirrhotic patients(18-70yrs) who never had encephalopathy

Exclusion Criteria:

• history of taking lactulose in the past 6 weeks

• alcohol intake during the past 6 weeks

• hepatocellular carcinoma

• previous TIPS or shunt surgery

• significant co morbid illness such as heart, respiratory, or renal failure

• neurologic diseases such as alzheimer's disease, parkinson's disease and nonhepatic metabolic encephalopathies.

• patients on psychoactive drugs such as antidepressants or sedatives

• who restarted alcohol during follow up