Probiotic Intervention After Surgical Removal of Mandibular Third Molars

• Status: Completed
• Trial end date: 2017-05-01
• Target enrollment: 0
• Participant gender: All

Summary

Single-center, double-blind, randomized trial of probiotics L. plantarum KABP-051 (CECT7481) and L. brevis KABP-052 (CECT7480) taken twice daily for 7 days after surgical removal of both mandibular 3rd molars. Patients were assessed for surgery-derived complications in a follow-up visit 7 days after surgery, and provided daily evaluations of pain, swelling and eating difficulty in a patient diary.

• Phase: N/A
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: AB Biotics, SA
• Collaborator: Hospital de Nens de Barcelona
• Treatments: Ibuprofen

Criteria

Inclusion Criteria:

• Otherwise healthy male and female undergoing surgical removal of both third mandibular molars.

• Aged between 14 and 25 years.

• Providing informed consent if 18yr and older, or parents/guardians providing informed consent otherwise

Exclusion Criteria:

• Subjects with gingival index (GI; according to Loe and Silness. 1963) or dental plaque index (PlI; according to Silness and Loe. 1964) above 2 in the CPI Community Periodontal Index) teeth subset.

• Subjects having used probiotics or antibiotics within 30 days prior to study enrollment.

• Tobacco use

• Pregnant and breastfeeding women.

• Known allergies to ingredients in study products.

• Not willing to refrain from using mouthwashes during the study period