Probiotic in Dry Eye Syndromes

• Status: Not yet recruiting
• Trial end date: 2021-10-30
• Target enrollment: 0
• Participant gender: All

Summary

This study will evaluate efficacy and safety of systemic and ophthalmic probiotic from bacterial lysate of Lactobacillus sakei on microbiota, immunological and clinical outcomes of patients with Dry Eye Syndrome.

• Phase: Phase 2
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Shiraz University of Medical Sciences

Criteria

Inclusion Criteria:

• M or F

• 18- BCVA>=9/10

• Signed informed consent, voluntary adherence to treatment

Exclusion Criteria:

• Pregnancy/breastfeeding

• Conjunctivitis

• Thyroid disease

• Diabetes

• Rheumatologic diseases including Sjogren's syndrome

• Neurologic conditions, including stroke, Bell's palsy, Parkinson's, trigeminal nerve problem

• Refractive surgery (LASIK or PRK)

• Other Eye Surgeries

• HSV Keratitis

• Medication/supplement use, including psychiatric medicines, OTC cold medicines, anti-histamines, beta-blockers, pain relievers, sleeping pills, diuretics, Hormones replacement, and oral contraceptives

• Chemical splashes / injuries to the eyes

• Contact lens use

• Environmental (dusty, windy, hot/dry)

• Any treatment for dry eye in previous 4 weeks (including lubricants, steroids, cyclosporine)