Probiotics Attenuate Postoperative Cognition Decline

• Status: Not yet recruiting
• Trial end date: 2021-12-31
• Target enrollment: 0
• Participant gender: All

Summary

The aim of this study was to evaluate whether perioperative probiotics can reduce the incidence of postoperative cognitive dysfunction and postoperative delirium.

• Phase: N/A
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: RenJi Hospital

Criteria

Inclusion Criteria:

1. . Age is greater than or equal to 65 years old

2. . Can communicate normally

3. . Selective knee ankle, hip replacement or lumbar open reduction and internal fixation under general anesthesia

4. . ASA graded at I-II level

5. . Patient or family informed consent

Exclusion Criteria:

1. . Have a brain disease, or have a history of brain disease

2. .MMSE check of less than 24 points.

3. . History of neurological and psychological disorders including AD, stroke, psychosis

4. . Serious hearing or visual impairment

5. . Preoperative systolic blood pressure >190mmhg, or diastolic blood pressure >100mmhg

6. . The patient or family refuses