Dysbiosis, or disruption of the gut microbiota, leads to the onset of autoimmunity.
Increasing data suggest that the gut microbiota is changed in various murine lupus models as
well as in human systemic lupus erythematosus SLE patients. Ingestion of lactobacilli, which
have immunoregulatory properties, may be a viable strategy for controlling disease
development and progression in patients with lupus, such as increasing the remission period
and decreasing flare frequency.