Prodrome-Based Early Intervention With Antipsychotics vs. Benzodiazepines in First-Episode Schizophrenia

• Status: Completed
• Trial end date: 2006-06-01
• Target enrollment: 0
• Participant gender: All

Summary

Prodrome based early intervention with an antipsychotic drug vs. benzodiazepine was applied in patients with first episode schizophrenia after one year neuroleptic maintenance treatment. Two groups of patients were followed over a period of 1 year: one further on under maintenance neuroleptic treatment, the other one after stepwise drug discontinuation.

• Phase: Phase 4
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Heinrich-Heine University, Duesseldorf
• Collaborators: German Federal Ministry of Education and Research; German Research Network On Schizophrenia; Humboldt-Universität zu Berlin; Janssen-Cilag Ltd.; Ludwig-Maximilians - University of Munich; Mainz University; Martin-Luther-Universität Halle-Wittenberg; RWTH Aachen University; Universität Duisburg-Essen; University Hospital Tuebingen; University of Bonn; University of Cologne; University of Göttingen; University of Jena; University of Mannheim; University of Wuerzburg
• Treatments: Antipsychotic Agents; Lorazepam

Criteria

Inclusion Criteria:

• First-episode in schizophrenia (according ICD-10 F20)

• Age between 18 and 55

• Informed consent

• One year neuroleptic maintenance treatment

Exclusion Criteria:

• Residence outside of the catchment area

• Legal reasons

• Insufficient knowledge of the german language

• Substance abuse or addiction

• Pregnancy

• Serious physical illness

• Organic brain disease

• Contraindication to neuroleptic treatment