Objective: To study the influence of metabolic factors on the action of progesterone on the
endometrium of women with PCOS.
Design: A prospective open-label clinical trial. Setting: Participants were recruited from an
outpatient reproductive endocrinology clinic at an academic tertiary medical care center from
2014 to 2019.
Subjects: To assess the sole effect of progesterone (P4) on the endometrium we studied
amenorrheic (cycles> 90 days) women with PCOS (n=23), comparing them to healthy eumenorrheic
control women ( n=13).
Intervention(s): All subjects underwent an endometrial biopsy (EB) in the follicular phase of
the first study cycle. They were then treated with micronized P4 (400 mg/day x 10 days
intravaginally) from days 14-28 of the cycle, and a second EB was performed between days
20-24 of the cycle (second phase).
Main Outcome Measure(s): EB samples were analyzed under light microscopy for
histomorphometric analysis.
Phase:
N/A
Details
Lead Sponsor:
University of Sao Paulo General Hospital
Collaborators:
Gustavo Arantes Rosa Maciel José Maria Soares Júnior Manuel de Jesus Simões Maria Cândida Pinheiro Baracat Ricardo Azziz Ricardo dos Santos Simões