Progesterone Treatment for Cocaine-dependent Women: A Pilot Study
Status:
Completed
Trial end date:
2012-09-01
Target enrollment:
Participant gender:
Summary
The purpose of this pilot treatment trial is to evaluate the efficacy of oral micronized PROG
in cocaine-dependent women. Since we have shown (Evans & Foltin, 2006) that oral micronized
PROG attenuates the positive subjective effects of smoked cocaine in females, but not in
males, and we have preliminary data indicating that oral micronized PROG also reduces smoked
cocaine self-administration in the laboratory, PROG appears to be an ideal potential
candidate medication to evaluate in cocaine-dependent women. Prior to randomization to
treatment, women will reside inpatient for one week to ensure cocaine abstinence since one of
the primary outcome measures will be time to cocaine relapse.