Progesterone Versus Progesterone Plus Dydrogesterone in FET
Status:
Completed
Trial end date:
2021-01-31
Target enrollment:
Participant gender:
Summary
Frozen embryo transfer (FET) has been increasing important in IVF. Progesterone is essential
for the endometrial secretory transformation, establishment and maintenance of pregnancy. In
FET, as there is neither corpus luteum nor the support of hCG, the role of progesterone is
even more important to ensure a sufficient luteal phase support.
Vaginal progesterone has been the most common preparation for luteal support in fresh embryo
transfer during IVF because of their ease of use and comparable effectiveness compared to
intramuscular progesterone. Recently, there was evidence of the considerable variation in
uptake, absorption and metabolism of intra-vaginal micronized progesterone. Dydrogesterone
alone has described to have similar effectiveness, safety and tolerability prolfiles for
luteal phase support compared to vaginal progesterone in luteal phase support for fresh
embryo transfer. This prospective study compares the effectiveness of micronized progesterone
versus micronized progesterone plus dydrogesterone for luteal phase support in FET.