Progesterone and Doppler in Recurrent Abortion

• Status: Unknown status
• Trial end date: 2019-12-05
• Target enrollment: 0
• Participant gender: Female

Summary

Recurrent pregnancy loss is classically defined as the occurrence of three or more consecutive pregnancy loss. The American Society of Reproductive Medicine has recently redefined recurrent pregnancy loss as two or more pregnancy losses. A pregnancy loss is defined as a clinically-recognized pregnancy means that the pregnancy has been visualized on an ultrasound or that pregnancy tissue was identified after a pregnancy loss.

• Phase: Phase 4
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: Assiut University
• Treatments: Dydrogesterone; Progesterone

Criteria

Inclusion Criteria:

1. pregnant 7-12 weeks documented by pregnancy test &/or ultrasaound.

2. History of at least 2 prior spontaneous abortion before 12 weeks of gestation.

3. Age: 18-35 years

4. Willing and able to give informed consent.

5. Rh +ve patient

6. BMI: 18-32

7. Viable pregnancy through the detection of fetal pulsations by ultrasound

8. Singleton pregnancy

9. Apparently stable pregnancy (no history of vaginal bleeding in this current pregnancy or signs of sac separation in ultrasound)

Exclusion Criteria:

1. Patients diagnosed to have Anti-phospholipid syndrome or another recognised thrombophilic or autoimmune conditions.

2. Pregnant > 12 weeks.

3. Contraindication to progesterone use.

4. Diabetic patients, have glucose intolerance.

5. Multiple pregnancies.

6. Thyroid disorder