Progesterone as Luteal Support in Frozen IVF Natural Cycles

• Status: Recruiting
• Trial end date: 2024-06-30
• Target enrollment: 0
• Participant gender: Female

Summary

The ProFET study aims to investigate if luteal phase support by vaginal progesterone, is superior to no luteal phase support, in terms of live birth rate per woman after a frozen embryo transfer (FET), in a natural cycle (NC) after in-vitro fertilization (IVF), and if 7 weeks of treatment is superior to 3 weeks duration.

• Phase: Phase 4
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Vastra Gotaland Region
• Collaborator: Göteborg University
• Treatments: Progesterone

Criteria

Inclusion Criteria:

• Planned for a FET-NC with a blastocyst

• BMI >18.5 <35

• Regular menstrual cycles 24-35 days

• Given informed consent

• Understand written and spoken Swedish, English or Arabic

Exclusion Criteria:

• Oocyte donor cycles, preimplantation genetic testing (PGT) cycles. Uterine malformation, submucous myoma and endometrial polyps.

• Hypersensitivity against study medication. Other contraindications according to www.fass.se

• Development of serious disease contraindicating ART or pregnancy.

• Participation or recent participation in a clinical study with an investigational product (past 30 days). Previous participation in this study.