Progesterone for the Treatment of Cocaine Dependence - 1

• Status: Completed
• Trial end date: 2008-06-30
• Target enrollment: 0
• Participant gender: All

Summary

Past research has demonstrated that cocaine dependent women experience less severe responses to cocaine during the luteal phase of the menstrual cycle, when estrogen and progesterone concentrations are high. The purpose of this study is to determine whether administered progesterone reduces subjective and physiological responses to cocaine in cocaine dependent individuals.

• Phase: N/A
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: University of Minnesota; University of Minnesota - Clinical and Translational Science Institute
• Collaborator: National Institute on Drug Abuse (NIDA)
• Treatments: Cocaine; Progesterone

Criteria

Inclusion Criteria:

• Smoked at least 1 gram of cocaine each week for the 6 months prior to study entry

• Agrees to use an adequate method of contraception for the duration of the study

• If female, current regular menses

Exclusion Criteria:

• Major psychiatric illnesses, including psychotic mood and anxiety disorders

• Current dependence on alcohol or drugs other that cocaine or nicotine

• History of major medical illnesses, including liver disease, abnormal vaginal bleeding, suspected or known breast cancer, thrombophlebitis, or other medical conditions

• Current use of oral contraceptives or other types of hormonal contraceptives

• Amenorrhea

• Currently on parole or probation

• Received treatment for chemical dependency within the 6 months prior to study entry

• Known allergy to progesterone or peanuts