Progestin Primed Double Stimulation Protocol Versus Flexible GnRH Antagonist Protocol in Poor Responders
Status:
Not yet recruiting
Trial end date:
2021-12-01
Target enrollment:
Participant gender:
Summary
The worldwide prevalence of primary and secondary infertility is estimated at ~2% and 10.5%,
respectively, among women aged 20-44 years and attempting to conceive. These women may enter
an IVF program and be classified as poor prognosis patients for several distinct causes (e.g.
advanced maternal age, low ovarian reserve). proper tailoring of the ovarian stimulation
protocol to maximize the number of oocytes collected represents a crucial step for them to
eventually conceive .
Recent evidence indicates that in the same menstrual cycle, there are multiple follicular
recruitment waves. This is in accord with the theory that folliculogenesis occurs in a
wave-like fashion. Thus, within a single menstrual cycle, there can theoretically be multiple
opportunities for a clinician to collect oocytes, as opposed to the conventional single
cohort of antral follicles during the follicular phase .
Utilizing this concept, reproductive endocrinologists have been attempting to retrieve
oocytes from poor responders using both the follicular-phase stimulation (FPS) and the
luteal-phase stimulation (LPS) protocols in order to increase the number of oocytes collected
shorter period of time. The number of oocytes collected in IVF is a robust surrogate outcome
for clinical success since there is a clear relationship between the number of oocytes
collected and live birth rates across all female age groups.
which protocol is the most effective remains controversial and the efficacy of PPOS in POR
compared with that of conventional protocols is unclear.
Phase:
Phase 3
Details
Lead Sponsor:
El Shatby University Hospital for Obstetrics and Gynecology