Project PROTECT: Protecting Nursing Homes From Infections and Hospitalization

• Status: Active, not recruiting
• Trial end date: 2023-12-01
• Target enrollment: 0
• Participant gender: All

Summary

This is a cluster-randomized trial of nursing homes to assess whether decolonization with routine chlorhexidine bathing and periodic use of nasal antiseptics can reduce hospitalizations associated with infections, antibiotic utilization, and multi-drug resistant organism (MDRO) prevalence. The comparator arm will be routine bathing care.

• Phase: Phase 4
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: University of California, Irvine
• Collaborators: Agency for Healthcare Research and Quality (AHRQ); Los Angeles Biomedical Research Institute; Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center; University of Massachusetts, Amherst
• Treatments: Chlorhexidine; Chlorhexidine gluconate; Povidone; Povidone-Iodine

Criteria

Inclusion Criteria

Nursing homes will be eligible to participate if they meet the following criteria:

• Licensed nursing home in Orange County or Southern Los Angeles County serving adults

• Minimal use of chlorhexidine bathing*

• Minimal use of nasal decolonization* *Minimal use defined as <15% of residents receiving at least one chlorhexidine bath or nasal decolonization treatment during their nursing home stay.

Exclusion Criteria

Nursing homes will not be eligible to participate if they meet the following criteria:

• Facilities routinely using decolonization

• Dedicated psychiatric nursing homes

• Facilities with a resident population with >=20% combative patients

• Pediatric facilities

Note: in any participating nursing home, residents with active end-of-life comfort care only measures are excluded