Prolotherapy Intervention Effect in Patient With Knee Osteoarthritis
Status:
Completed
Trial end date:
2020-08-01
Target enrollment:
Participant gender:
Summary
Introduction :
Prolotherapy is regenerative tissue therapy which is considered to be efficacious in reducing
symptoms and morbidity of Knee Osteoarthritis (KOA), but only a few studies demonstrate the
effect of prolotherapy at the biomolecular level, particularly the level of Cartilage
Oligomeric Matrix Protein (COMP), and Urinary C-Terminal Telopeptides of Type II Collagen
(uCTX-II) as the biomarkers of cartilage repair.
Objective:
To determine the effect of prolotherapy on COMP and uCTX-II levels, and functional outcomes
in KOA patients.
Method:
a double-blind randomized controlled trial study involving 36 participants who had been
diagnosed with KOA. History taking, functional outcome assessment, COMP, and uCTX-II were
measured. The prolotherapy via intraarticular and extraarticular was performed at Day-1,
Day-29, and Day-57 followed by the evaluation of functional outcome, COMP, and uCTX-II at day
78
Alternative Hypothesis :
Prolotherapy provides improvement of cartilage based on COMP and UCTX-II levels and
functional outcome among KOA patients