Prolotherapy Intervention in Patient With Frozen Shoulder
Status:
Recruiting
Trial end date:
2022-04-30
Target enrollment:
Participant gender:
Summary
Introduction :
Prolotherapy is regenerative tissue therapy that is considered to be efficacious in reducing
symptoms and morbidity of frozen shoulder, but only a few studies demonstrate the effect of
prolotherapy at the biomolecular level, particularly the level of Matrix Metalloproteinase- I
(MMP-1), Tissue Inhibitor Matrix Metalloproteinase (TIMP-1), as the biomarkers of cartilage
repair.
Objective:
To determine the effect of prolotherapy on MMP-1, TIMP-1, and functional outcomes in frozen
shoulder patients
Method:
a double-blind randomized controlled trial study involving participants who had been
diagnosed with Frozen Shoulder. History taking, functional outcome assessment, MMP-1, and
TIMP-1 were measured. The prolotherapy via intraarticular and extraarticular was performed
four times, followed by the evaluation of functional outcome, MMP-1, and TIMP-1 at week 12
Alternative Hypothesis :
Prolotherapy will increase the MMP-1, TIMP-1 levels, and improve functional outcome among
Frozen Shoulder patients