Propanolol and Red Cell Adhesion Non-asthmatic Children Sickle Cell Disease
Status:
Terminated
Trial end date:
2013-04-03
Target enrollment:
Participant gender:
Summary
Propanolol is a beta blocker which has been found to inhibit the ability of epinephrine to
upregulate sickle red cell adhesion to laminin and endothelial cells in vitro. The purpose of
this pilot study is to administer one dose of propanolol to children with sickle cell disease
and to measure pre and post dose red cell adhesion. The hypothesis is that a single dose of
propanolol will decrease red cell adhesion to laminin and endothelial cells as compared to
baseline.