Overview

Prophylactic Antibiotics Useful With Antibiotic Impregnated External Ventricular Drains (EVDs)?

Status:
Active, not recruiting

Trial end date:
2023-07-14

Target enrollment:
0

Participant gender:
All

Summary

The length of prophylactic antibiotic use with antibiotic impregnated External Ventricular Drains (EVD)s is unknown. This study is a randomized clinical trial with two arms: 1. twenty four hours of prophylactic antibiotic use or 2. prophylactic antibiotic use for entire duration of EVD

Phase:

Phase 1

Accepts Healthy Volunteers?

Details

Lead Sponsor:

Montefiore Medical Center

Treatments:

Anti-Bacterial Agents
Antibiotics, Antitubercular

Criteria

Inclusion Criteria:

- patients over the age of 18 years and patients diagnosed with a subarachnoid
hemorrhage, intracerebral hemorrhage or acute ischemic stroke who require an EVD for
management of their underlying condition.

- In certain cases (a small minority), an EVD must be replaced due to failure (i.e.;
blood clot interrupting flow). In such cases, patients will be re-dosed with
antibiotics prior to catheter exchange in typical fashion, and continue in their
previously randomized treatment group.

Exclusion Criteria:

- patients who underwent any intracranial procedure in the 30 days prior,

- patients who were on antibiotics within the week prior to admission,

- patients with leukopenia (<5000) at baseline,

- patients with signs of meningitis, ventriculitis or any other infection at
presentation,

- patients who are pregnant or prisoners.

- patients aged < 18 years old