Prophylactic Antibiotics for Manual Removal of Retained Placenta in Vaginal Birth: a Randomized Controlled Trial
Status:
Unknown status
Trial end date:
1969-12-31
Target enrollment:
Participant gender:
Summary
Background: There is scarce evidence regarding the necessity of antibiotic prophylaxis in
manual revision of the uterus after labor in cases of residual placenta.
Methods: a randomized control trial in which parturients for which the placenta was not
separated or there is a suspected residual placenta will be divided randomly to two groups:
(1) Revision of uterus or Manual lysis without antibiotic prophylaxis; (2) Revision of uterus
or Manual lysis with antibiotic prophylaxis as following: 24 hours coverage with Ampicillin 2
grams*4, Gentamycin 240 mg*1, Clindamycin 600 mg*3. In cases of allergy to Penicillin the
antibiotic regimen will be: Gentamycin 240 mg*1, Clindamycin 600 mg*3.
Outcomes: Puerperal fever, endometritis, length of hospitalization after labor, recurrent
hospitalization in the first 2 weeks after discharge.