Prophylactic Antibiotics for Prevention of Wound Complications Following Vulvectomy

• Status: Completed
• Trial end date: 2009-04-01
• Target enrollment: 0
• Participant gender: Female

Summary

This randomized prospective study will specifically investigate the efficacy of a 24 hour post-operative course of broad-spectrum prophylactic antibiotics - namely Cefazolin - in preventing wound infection and wound breakdown following vulvectomy.

• Phase: Phase 4
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Aultman Health Foundation
• Treatments: Anti-Bacterial Agents; Antibiotics, Antitubercular; Cefazolin; Cephalosporins; Clindamycin; Clindamycin palmitate; Clindamycin phosphate; Polystyrene sulfonic acid

Criteria

Inclusion Criteria:

• All female patients 18 years of age or older undergoing surgery for vulvar carcinoma (this includes female patients undergoing any form of vulvectomy - radical, vulvectomy without groin node dissection, and partial vulvectomy)

• Disease State will not affect inclusion in the study. Women with previous surgery for vulvar carcinoma will be included as will those undergoing initial operation.

• Number of subjects: 160

Exclusion Criteria:

• Women simultaneously undergoing treatment for other forms of cancer

• Women under the age of 18

• Pregnant patients