Prophylactic Antibiotics in Comatose Survivors of Out-of-hospital Cardiac Arrest

• Status: Completed
• Trial end date: 2015-04-01
• Target enrollment: 0
• Participant gender: All

Summary

The purpose of this study is to determine whether there is potential benefits of prophylactic antibiotic treatment in comatose survivors of out-of-hospital cardiac arrest (OHCA) treated in intensive care unit with therapeutic hypothermia.

• Phase: Phase 4
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: University Medical Centre Ljubljana
• Treatments: Amoxicillin; Amoxicillin-Potassium Clavulanate Combination; Anti-Bacterial Agents; Antibiotics, Antitubercular; Clavulanic Acid; Clavulanic Acids

Criteria

Inclusion Criteria:

• Female and male over 18 years old

• Comatose survivors of out-of-hospital cardiac arrest treated in intensive care unit with therapeutic hypothermia

Exclusion Criteria:

• Suspected or confirmed pregnancy

• Allergy to amoxicillin-clavulanic acid

• Tracheobronchial aspiration

• Antibiotic therapy before cardiac arrest

• Need of antibiotics due to other causes

• Candidates for immediate veno-arterial extracorporeal membrane oxygenation (VA ECMO)

• Patients in whom no active treatment was decided on admission