Prophylactic Antibiotics in Cystectomy With Diversion

• Status: Recruiting
• Trial end date: 2026-10-15
• Target enrollment: 0
• Participant gender: All

Summary

Using a randomized 2 arm design, this study is being conducted to test for non-inferiority of no prophylactic antibiotic therapy versus the prophylactic oral antibiotic, nitrofurantoin, through comparison of rates of postoperative urinary tract infections within the 90-day postoperative period in patients with muscle invasive bladder cancer who undergo radical cystectomy with urinary diversion.

• Phase: Early Phase 1
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: University of Minnesota
• Treatments: Anti-Bacterial Agents

Criteria

Inclusion Criteria:

• Presence of muscle invasive bladder cancer and planning to undergo radical cystectomy with either ileal conduit or neobladder diversion.

• 18 years of age or older

Exclusion Criteria:

• Currently receiving antimicrobials for active infection

• Poor renal function with GFR < 30 ml/min

• Allergy to nitrofurantoin and unable to take an alternative antibiotic (cephalexin, trimethoprim-sulfamethoxazole, or ciprofloxacin)

• Pregnancy

• Unable to provide Informed consent