Prophylactic Effect of Nifedipine on Further Decline in Renal Function in Patients Undergoing Open-Heart Surgery
Status:
Completed
Trial end date:
2005-10-01
Target enrollment:
Participant gender:
Summary
To compare renal function (51Cr-EDTA clearance) 48 hours post open-heart surgery (coronary
bypass or valve surgery) in patients with impaired renal function after randomization to
either nifedipine infusion at start of surgery and the following 24 hours or placebo (0.9%
saline infusion). Study hypothesis is that nifedipine has a prophylactic effect on decline in
renal function.