Prophylactic Effects of Ondansetron, Ramosetron, and Palonosetron on Patient-Controlled Analgesia Related Nausea and Vomiting After Urologic Laparoscopic Surgery

• Status: Completed
• Trial end date: 2011-06-01
• Target enrollment: 0
• Participant gender: Female

Summary

The aim of this prospective randomized controlled study was to compare the prophylactic effects of intravenous single dose of ondansetron, ramosetron, and palonosetron on PCA-related nausea and vomiting after urologic laparoscopic surgery.

• Phase: N/A
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Yonsei University
• Treatments: Ondansetron; Palonosetron; Ramosetron

Criteria

Inclusion Criteria:

• ASA I or II

• Patients aged (20-65 yr) Undergoing Laparoscopic Nephrectomy

• Patients who want a patient-controlled IV analgesia (IV-PCA)

Exclusion Criteria:

• History of allergy or hypersensitivity to 5-HT3 antagonist

• History of severe postoperative nausea/vomiting

• Prolonged QT interval on preoperative EKG

• Hypokalemia, Hypomagnesemia

• Intestinal obstruction

• Pregnant female or breast feeding mother