Prophylaxis Ephedrine or Ondansetron Prevents Hypotension After Spinal Anesthesia for Cesarean Section
Status:
Completed
Trial end date:
2015-03-01
Target enrollment:
Participant gender:
Summary
Maternal hypotension after spinal anesthesia in parturients undergoing cesarean section is a
very common problem leading to several complications to both patients and their babies. It
can cause maternal discomfort, lightheadedness, nausea and vomiting. The most important
complication is the decreasing blood flow to babies; which may lead to fetal acidosis.
Many interventions has been studied in order to prevent hypotension after spinal anesthesia
in cesarean section e.g., fluid loading: colloid vs crystalloid, medications: ephedrine,
phenylephrine, and metaraminol, etc. The recent study showed ondansetron (the antiemetic
drug) can be effectively used to prevent hypotension after spinal anesthesia in normal
patients or parturients. The action of ondansetron is believed to inhibit Bezold-Jarish
reflex.
This aim of this study is to compare the efficacy of ephedrine and ondansetron in the
prevention of maternal hypotension after spinal anesthesia in cesarean section.