Prophylaxis to Reduce Postoperative Atrial Fibrillation in Cardiac Surgery

• Status: Completed
• Trial end date: 2012-02-01
• Target enrollment: 0
• Participant gender: All

Summary

Atrial Fibrillation (AF) is a common postoperative complication of cardiac surgery, occuring in approximately 25-30% of coronary artery bypass graft (CABG) patients and 35-40% of heart valve repair/replacement patients. Efforts to decrease the high rates of AF have not made great inroads to the problem. The current standard of care is the use of preoperative and postoperative beta blockers. We propose to compare the use of prophylactic oral ascorbic acid with and without prophylactic oral amiodarone, in combination with oral beta blockers, for the prevention of atrial fibrillation after open heart surgery. The hypothesis is that either drug, or a combination of the two drugs, will be superior and safe when compared to beta blockers alone.

• Phase: Phase 3
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Maine Medical Center; MaineHealth
• Treatments: Adrenergic beta-Antagonists; Amiodarone; Ascorbic Acid; Metoprolol

Criteria

Inclusion Criteria:

• adults (18 years of age or older)

• all comers for elective or urgent open heart surgery ( CABG, Valve repair or replacement, Combined CABG/Valves, CABG/other, Other)

Exclusion Criteria:

• patients who refuse to participate

• patients with a history of atrial fibrillation or atrial flutter

• pediatric patients (under 18 years of age)

• Emergency surgery

• patients with contraindications to study medications

• patients with untreated thyroid disease, hepatic failure, pregnancy