Propofol Effect-Site Target Controlled Infusion in the Obese: Characterization of the Time Profile of Bispectral Index Response

• Status: Completed
• Trial end date: 2011-11-01
• Target enrollment: 0
• Participant gender: All

Summary

The aim of this study is to characterize the Pharmacokinetic/Pharmacodynamic relationship of a single bolus dose of propofol in obese patients and to extract a time to peak effect (t-peak) from the estimated model parameters.

• Phase: Phase 4
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: Universidad del Desarrollo
• Treatments: Propofol

Criteria

Inclusion Criteria:

• IMC > 35 kg m-2

• Scheduled for laparoscopic bariatric surgery

• ASA I-II patients

• Between 20 and 60 yr of age.

Exclusion Criteria:

• Patients with allergy to study drugs

• Uncontrolled hypertension

• Heart block greater than first degree

• Take any drug acting in the central nervous system