Propofol Pharmacokinetics and Pharmacodynamics Modelling

• Status: Completed
• Trial end date: 2017-04-28
• Target enrollment: 0
• Participant gender: All

Summary

The main purpose of this research is to develop a population pharmacokinetic and pharmacodynamic model of Propofol when used for induction and maintenance of anaesthesia, using BIS as a pharmacodynamic endpoint.

A covariate analysis will be performed in order to account for variability in pharmacokinetic and pharmacodynamic parameters. The influence of age and obesity on propofol pharmacokinetic parameters will be particularly addressed.

• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Centro Hospitalar do Porto
• Treatments: Propofol

Criteria

Inclusion Criteria:

• Adult patients admitted for nose or ear surgery, bariatric surgery or urgent orthopaedic surgery.

Exclusion Criteria:

• Severe hepatic or renal insufficiency;

• Significant haemodynamic instability previous to the surgery;

• Allergy to eggs or propofol at the time of enrolment;

• Predictive criteria for difficult airway management.